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KMID : 0380620070390020217
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Korean Journal of Food Science and Technology
2007 Volume.39 No. 2 p.217 ~ p.221
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Antioxidant Effects of Ginseng Powder on Liver of Benzo(α)Pyrene-treated Mice
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Kim Hyun-Jeong
Lee In-Seon
HwangBo Mi-Hyang
Lee Ji-Won
Im Hyo-Gwon
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Abstract
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In order to determine the effects of ginseng powder on the antioxidant enzyme activities of hepatotoxicity in mice, the mice were divided into 5 groups. Ginseng powder was injected intraperitoneally once a day for 5 successive days, followed by the administration of treatment on the fifth day. We also evaluated the relationship existing between lipid peroxidation and ginseng powder on oxidative stress. The increased activities of superoxide dismutase, catalase, and glutathione peroxidase observed following were reduced as the result of ginseng powder treatment. Whereas, the glutathione content and glutathione S-transferase activity depleted by were increased significantly, but the elevation of cytochrome P-450 activities and lipid peroxide content were reduced as the result of ginseng powder treatment. These results indicate that ginseng powder may exert a protective effect against hepatotoxicity in mice.
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KEYWORD
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ginseng powder, B(α)P, hepatotoxicity, antioxidant activity
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